Learn more about our neurotransmitter imaging work with this talk, presented at the Brain and Behavior Research Foundation (BBRF) Annual Research Symposium, this news story about the role of neurochemistry in social attachment, and this article from the San Francisco Chronicle.
Information transfer in living organisms occurs over many length and time scales. A prime example of this complexity is the nervous system, where neurotransmitters are released between neuronal cells across nanometer-scale synapses, yet this chemical communication drives functionality on the macroscopic scale of the organism. The difficulty in developing tools to study neurotransmission lies in the complexity of extending such tools over the many orders of magnitude spanned by the nervous system. As such, tools to study neurotransmission are segmented and optimized to acquire information for small ranges of spatial and temporal information (i.e. single-neuron fluorescence imaging vs. whole-brain functional mapping).
Our lab develops tissue-compatible sensors for modulatory neurotransmitters that can report on neurotransmitter concentrations in brain tissue, at spatial and timescales that match the complexity of neurotransmission. With these nanosensors, we seek to explain how environmental stimuli can affect chemical neurotransmission. Our aim is to complement the knowledge base of how brain structure (fluorescence microscopy), and behavior (psychology), affect the release and re-uptake of chemical neurotransmitters, and how synaptic-level changes in neurochemical signaling vary across a range of neurotypical processes and also across various psychiatric and neurodegenerative disorders. We have several active research projects studying the synaptic-scale neurochemical signaling differences in animal models of addiction, Huntington’s disease, and autism spectrum disorder.
.
See press coverage of our work for imaging brain chemistry:
.
.
.
Scientists: Madeline Klinger, Jaewan Mun, Natsumi Komatsu, Shoichi Nishitani, Jaquesta Adams.
Select Publications: Beyene et al. ACS Chemical Neuroscience 2017 || Del Bonis O’Donnell et al. Advanced Functional Materials 2017 Beyene et al. Science Advances 2019 || Jeong et al. Science Advances 2019 || Yang et al. ACS Nano 2020 || Yang et al. Nature Protocols 2021 || Sorooshyari et al. ACS Chemical Neuroscience (2023)|| Mun et al. PNAS (2024) ||