Our research lies at the intersection of single-molecule biophysics and nanomaterial-polymer science to develop new tools to probe and characterize complex biological systems. In particular, near-infrared emitters (fluorophores, zero-dimensional, and one-dimensional nanomaterials) provide emission wavelengths that are maximally permeable to biological materials. As such, we explore the potential of near-infrared and large stokes shift light emitters combined with conventional visible fluorophores to detect molecular processes in systems that are optically and physically dense. We develop these tools for single-molecule applications, with the goal of scaling them to the study of molecular processes in whole-organisms. We further explore nanoscale materials as scaffolds for the delivery of biological molecules into tissues, cells, and sub-cellular organelles. To these ends, we build and develop optical microscopy tools, functionalize and characterize nanomaterials, and combine these areas for in vitro and in vivo molecular detection.

 

Our research is supported by


  bwf        narsad

     simons-logo     Beckman foundation

      NSF-logosas